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Efficient preparation of two benzyl alcohol by three methods

date:2017-07-10 21:49   author:admin click:
  Efficient preparation of two benzyl alcohol by three methods:
First, two benzyl alcohol was prepared by zinc powder reduction method
In a reflux condenser 100mL conical flask 3G loaded with sodium hydroxide, two 3G benzophenone, 3G powder, 30mL95% ethanol, and 20min at room temperature of 80 degrees Celsius, water bath heating 5min, filtered, washed by ethanol precipitation, with the filtrate, ice bath cooling, accidentally dropping concentrated hydrochloric acid to a pH of 5 to 6. Choulv, solid and 30mL petroleum ether recrystallization to obtain acicular crystal benzophenone 2G about two degrees Celsius, the melting point 68-69.
Second, two phenyl ketone was reduced to two benzyl alcohol
 
  Using sodium borohydride reduction of two phenyl ketone prepared two benzyl alcohol, two phenyl ketone with rose fragrance, white crystal, the melting point of 47 to 49 DEG C, the boiling point of 306 DEG C, insoluble in water, soluble in ethanol, ether and chloroform and other organic solvents. Two benzophenone is an ultraviolet absorber and initiator. It is an intermediate of organic pigments, pharmaceuticals, spices and insecticides. It can give spices sweet flavor and is used in many perfumes and soap essences. Two benzyl alcohol is a colorless needle like crystal with melting point of 68~69 DEG C, boiling point 298 DEG C (1.0MPa) and 180 DEG C (2.67kPa). Soluble in ethanol, ether, chloroform and carbon disulfide and other organic solvents. Solubility in water at 20 0.5g/L. Mainly used for organic synthesis intermediates, pharmaceutical industry as benztropine and diphenhydramine.
Third. Preparation of two benzyl alcohol with phenyl magnesium bromide and Benzaldehyde
 
  1mol Grignard reagent was first prepared. In order to improve the efficiency, 2mol aldehyde was added to process the mixture to obtain crystalline products. However, two phenyl ketone was prepared. In this method, two ketone was then reduced to two benzyl alcohol! With sodium borohydride, lithium aluminum hydride or hydrogenation can be reduced; methods two: the experimental process should be added sodium borohydride, so that the production of two phenyl ketone reduced to two benzyl alcohol.
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